Cancer Drug Discovery by Kyu-Won Kim Jae Kyung Roh Hee-Jun Wee & Chan Kim

Author:Kyu-Won Kim, Jae Kyung Roh, Hee-Jun Wee & Chan Kim
Language: eng
Format: epub
Publisher: Springer Netherlands, Dordrecht

A study was performed on the anticancer effects of thalidomide by R. D’Amato and J. Folkman at Harvard University in 1994 [47]. They proposed that the deformities caused by thalidomide were a result of defective angiogenesis during the development and evaluated its effect on angiogenesis using animal models. They observed that along with an inhibitory effect on cancer growth thalidomide remarkably suppressed tumor angiogenesis. This led to various studies on the anticancer potential of thalidomide. B. Barlogie’s group at the University of Arkansas, in collaboration with J. Folkman, conducted a study using thalidomide mediated inhibition of angiogenesis to treat multiple myeloma with profound angiogenesis. In 1999, Barlogie’s group was the first to report that thalidomide was effective in treating multiple myeloma [48]. Following additional clinical trials, thalidomide was approved by the FDA as a therapeutic agent for multiple myeloma in combination with dexamethasone in 2006, and is still in clinical use.

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